| 缓释控释制剂的释放度测定方法的研究进展 |
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| 引用本文： | 常翠,杨宏图,董淳,毕殿洲. 缓释控释制剂的释放度测定方法的研究进展[J]. 现代食品与药品杂志, 2003, 13(2): 16-18 |
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| 作者姓名： | 常翠 杨宏图 董淳 毕殿洲 |
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| 作者单位： | 深圳市人民医院，深圳市人民医院，深圳市人民医院，沈阳药科大学药剂教研室 暨南大学第二附属医院药学部，广东518020，暨南大学第二附属医院药学部，广东518020，暨南大学第二附属医院药学部，广东518020，沈阳110015 |
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| 摘 要： | 目的 介绍缓、控释制剂的体外释放度测定方法 ,使其能更好地模拟体内状态。方法 综述最近的中外文献中有关缓释、控释制剂的体外释放度测定实验方法 ,实验条件的选择及影响因素。结果 体外释放度实验条件如释放介质的 pH值、离子强度、增溶剂、表面活性剂和释放仪器等可影响缓、控释制剂的体外释放度。结论 根据不同药物选择尽可能接近体内状态的方法
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| 关 键 词： | 体外释放度实验 缓释制剂 控释制剂 影响因素 |
| 文章编号： | 1007-9939(2003)02-0016-03 |
| 修稿时间： | 2002-09-11 |
Development of dissolution testing study for sustained or controlled release oral dosage forms |
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| Chang Cui,Yang Hongtu,Dong Chun,Bi Dianzhou. Development of dissolution testing study for sustained or controlled release oral dosage forms[J]. JOurnal of Modern Food and Pharmaceuticals, 2003, 13(2): 16-18 |
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| Authors: | Chang Cui Yang Hongtu Dong Chun Bi Dianzhou |
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| Abstract: | Objective Introduce the in vitro dissolution testing method for sustained or controlled release dosage forms,so that the in vivo state can be better simulated.Methods Summarize all current literatures about experimental methods,the choice and influence factors of experimental condition of in vitro dissolution testing.Results The experimental condition like the pH value and ion intensity of release medium,solubilizers,surfactants,release apparatus and so on can effect the in vitro dissolution testing of sustained or controlled release dosage forms.Conclusion Choose the methods are likely to in vivo state according to different drugs. |
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| Keywords: | experiment of in vitro dissolution testing sustained or controlled release dosage forms influence factor |
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