HEGPOL: Randomized,placebo controlled,multicenter, double-blind clinical trial to investigate hepatoprotective effects of glycine in the postoperative phase of liver transplantation [ISRCTN69350312] |
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| Authors: | Steffen?P?Luntz Kristina?Unnebrink Monika?Seibert-Grafe Hartwig?Bunzendahl Thomas?W?Kraus Markus?W?Büchler Ernst?Klar Email author" target="_blank">Peter?SchemmerEmail author |
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| Institution: | (1) Coordination Centre for Clinical Trials (KKS), University of Heidelberg, Germany;(2) Department of Surgery, University of Heidelberg, Germany;(3) Department of Surgery, University of North Carolina (UNC) at Chapel Hill, USA;(4) Department of Surgery, University of Rostock, Germany |
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| Abstract: | Background Kupffer cell-dependent ischemia / reperfusion (I/R) injury after liver transplantation is still of high clinical relevance,
as it is strongly associated with primary dysfunction and primary nonfunction of the graft. Glycine, a non-toxic, non-essential
amino acid has been conclusively shown in various experiments to prevent both activation of Kupffer cells and reperfusion
injury. Based on both experimental and preliminary clinical data this study protocol was designed to further evaluate the
early effect of glycine after liver transplantation. |
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