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| A-A大鼠模型足肿胀针灸方案优选对局部病理组织中ICAM-1表达的影响 | |
| 引用本文： | 李鑫元,郭荣胜,李元鑫,邹永艳,徐春梅,周振坤. A-A大鼠模型足肿胀针灸方案优选对局部病理组织中ICAM-1表达的影响[J]. 针灸临床杂志, 2011, 27(7): 65-70 |
| 作者姓名： | 李鑫元 郭荣胜 李元鑫 邹永艳 徐春梅 周振坤 |
| 作者单位： | 1. 哈尔滨医科大学附属第二医院,黑龙江哈尔滨,150086 2. 山东省威海市中医院,山东威海,264200 3. 黑龙江省中医研究院,黑龙江哈尔滨,150036 |
| 摘 要： | 目的:通过针灸治疗方案的优选治疗A-A足肿胀模型大鼠,观察该治疗方案对A-A的病理形态学变化及局部病理组织中ICAM-1表达的影响,分析其获效机理。方法:以A-A大鼠足肿胀度为观察对象,以A-A的病理形态学变化及局部病理组织中ICAM-1表达为指标,应用本实验前期采用的正交设计法进行方案优选及治疗观察。结果:采用火针局部和整体配穴可获得最佳消肿率和抑制病理进展、下调ICAM-1表达的效应。结论:针灸治疗RA具有延缓RA病理进展、减轻ICAM-1在RA局部病变滑膜组织中表达的作用;针灸对RA的治疗尤以火针疗效为最佳,艾灸疗效较好,局部与整体配穴具有协同意义。 |
| 关 键 词： | A-A大鼠 正交设计针灸优选方案 关节肿胀度 粘附因子 |
The Effect of Optimization of Acupuncture for A-A Rats' Models with Feet swell on the Expression of ICAM-1 of Local Pathological Tissues |
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| LI Xin-yuan,GUO Rong-sheng,LI Yuan-xin,ZOU Yong-yan,XU Chun-mei,ZHOU Zhen-kun. The Effect of Optimization of Acupuncture for A-A Rats' Models with Feet swell on the Expression of ICAM-1 of Local Pathological Tissues[J]. Journal of Clinical Acupuncture and Moxibustion, 2011, 27(7): 65-70 | |
| Authors: | LI Xin-yuan GUO Rong-sheng LI Yuan-xin ZOU Yong-yan XU Chun-mei ZHOU Zhen-kun |
| Affiliation: | LI Xin-yuan1,GUO Rong-sheng2,LI Yuan-xin3,ZOU Yong-yan3,XU Chun-mei3,ZHOU Zhen-kun3(1.Harbin Medical University,Harbin 150086,China,2.Weihai Hospital of TCM,Weihai 264200,3.Institute of Heilongjiang Chinese Medicine,Harbin 150036,China) |
| Abstract: | Objective:To select the optimal treatment program of acupuncture and moxibustion for foot swells in A-A rats,and to analyse the mechanism of its therapeutic effect. Methods:Fluoride's complete adjuvant to the A-A-induced rat paw edema of the subjects to pathological tissue for the expression of ICAM-1 indicator of orthogonal design factors affecting the efficacy of program optimization. Results:The best effect for getting littler swells rate,restraining pathologic progress and reducing the expression of ICA... |
| Keywords: | A-A rat Orthogonal design Optimization of acupuncture and moxibustion Degree of joint swell Intercellular adhesion molecule-1(ICAM-1) |
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