Effects of Coptis chinensis on Lipid Peroxidation and Antioxidases Activity of Rats

ＥｆｆｅｃｔｓｏｆＣｏｐｔｉｓｃｈｉｎｅｎｓｉｅｏｎＬｉｐｉｄＰｅｒｏｘｉｄａｔｉｏｎａｎｄＡｎｔｉｏｘｉｄａｓｅｓＡｃｔｉｖｉｔｙｏｆＲａｔｓＳｏｎｇＬｕ－ｃｈｅｎｇ（宋鲁成）；（ＳｈａｎｄｏｎｇＱｉａｎｆｅ－ｓｈａｎＨｏｓｐｉｔａｌ，Ｊｉｎａｎ）...

Effects of Coptis chinensie on Lipid Peroxidation andAntioxidases Activity of Rats

Coptis chinensis and the brain homogenate of rat were mixed and incubated to investi-gate the effects of Coptis on lipid peroxidation. The results showed that the malondialdehyde product ofrat brain homogenate inhibited by 5% Coptis was significantly different from that of the control group (P<0. 001). On the basis of the above-mentioned results, the effect of Coptis on lipid peroxidation and dia-betes in rats induced by alloxan was investigated. The results showed : (1) The malondialdehyde productof both the pancreas and liver homogenate in the Coptis (test) group was significantly less than that inblank control and the alloxan (control) group (P<0. 01 , P<0. 05). (2) Superoxide dismutases in erythro-cytes activity was the same for all groups (P>0. 50). (3) The blood catalase activity in the control groupmarkedly decreased compared with the blank control group (P<0. 05) , but no significant change betweenthe test and control group (P>0. 05) occurred. (4)The value of serum glucose in the control group wassignificantly increased compared with the blank control group (P<0. 05). A decrease in the value ofserum glucose in the test group compared with the control group occurred, but with no significant differ-ence between the two groups (P