应用超声心动图观察螺内酯对血吸虫性肺动脉高压的疗效

目的探讨螺内酯对血吸虫性肺动脉高压的影响。方法 62例血吸虫病所致肺动脉高压病人随机分为实验组(螺内酯组)和对照组,每组31例。观察两组患者治疗前后的肺动脉平均压、肺动脉直径、心功能和6 min步行试验的变化。结果治疗前后肺动脉平均压、肺动脉直径、心功能和6 min步行试验结果比较,螺内酯组差异有显著性(P<0.05),而对照组差异无显著性(P>0.05)。结论螺内酯能降低血吸虫性肺动脉高压病人的肺动脉压,并能改善肺功能。

Evaluation of therapeutic effects of spironolactone on schistosomal pulmonary arterial hypertension by echocardiography

Objective To evaluate the therapeutic effect of spironolactone on schistosomal pulmonary arterial hypertension(SPAH). Methods A total of 62 patients suffered from hepatosplenic schistosomiasis with pulmonary arterial hypertension were divided into the spironolactone group(n=31) and control group (n=31). All the patients underwent serial echocardiography and the clinical effect before and after the treatment was evaluated by assessing the mean pulmonary arterial pressure (mPAP) and pulmonary arterial diameter (PAD). At the same time, the varieties of the clinical symptoms, signs and the distance of the 6-minute walking test (6-MWT) were investigated. Results In spironolactone group, mPAP(-x±s) decreased from (31.8±7.1) mmHg to (21.2±2.1) mmHg, PAD(-x±s) decreased from (28.0±5.0) mm to (20.0±3.5) mm before and after the treatment respectively(P<0.01). There were significant differences in mPAP, PAD, the distance of 6-MWT and the heart function before and after the treatment in the spironolactone group. However, the data did not show the significant difference in the control group. Conclusion The therapeutic effect of spironolactone in the treatment of SPAH is satisfactory.