Role of human HGFIN/nmbin breast cancer |
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| Authors: | Rebecca L Metz Prem S Patel Meera Hameed Margaret Bryan Pranela Rameshwar |
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| Affiliation: | (1) Department of Medicine, UMDNJ-New Jersey Medical School, Newark, NJ, USA;(2) Department of Obstetrics, Gynecology and Women's Health, UMDNJ-New Jersey Medical School, Newark, NJ, USA;(3) Division of Trauma, Brookdale University Hospital and Medical Center, Brooklyn, NY, USA;(4) Department of Laboratory Medicine and Pathology, UMDNJ-New Jersey Medical School, Newark, NJ, USA |
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| Abstract: | Introduction HGFIN, previously identified as nmb, and its homolog osteoactivin are single transmembrane proteins that are expressed in differentiated immune cells. These proteins exhibit properties that could potentiate tumorigenesis or decrease invasiveness. These seemingly opposing roles of HGFIN suggest that this protein might be central to malignancies and might also behave as a tumor suppressor. Consistent with the reported roles for HGFIN is the fact that this gene is regulated by p53 through multiple binding sites in the 5' flanking region, and is expressed in osteoblasts. |
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