芪黄口服液治疗肝硬化患者肠道菌群紊乱的临床研究

目的研究芪黄口服液对肝硬化患者肠道菌群紊乱疗效及血浆内毒素水平的影响。方法70例肝硬化患者随机分为对照组和治疗组，并用相应药物治疗，观察两组患者治疗前后症状变化，定量检测大便常见的厌氧菌、需氧菌及血浆内毒素。结果治疗组在治疗后需氧菌量较治疗前明显下降，厌氧菌量明显升高，肠道菌群比例得到明显改善；临床症状改善，血浆内毒素明显降低，与对照组比较，差异有显著性(P＜0.05)。结论芪黄口服液能改善肠道菌群比例，使肠道厌氧菌数量增加，减少肠源性内毒素的产生、吸收，显著降低血浆内毒素水平，从而达到减轻肝损伤和改善病情。

Clinical Study on Effect of Qihuang Oral Liquid to Enteric Flora Disturbance and Serum Endotoxin Level in Patients of Liver Cirrhosis

To study the effect of Qihuang oral liquid (QHOL) in treating enteric flora disturbance and serum endotoxin level of liver cirrhosis patients. Methods: Seventy patients suffering from liver cirrhosis were randomized into the control group and the QHOL treated group. The symptomatic changes, quantitative determination of anaerobic and aerobic flora in feces as well as serum endotoxin level were observed before and after treatment. Results: In comparison with the control group, the treated group revealed a significantly better effects (P<0 05) in the following parameters: (1) reduction in aerobic and increase in anaerobic flora, thus to improve the ratio of enteric flora; (2) improvement in clinical symptoms; (3)lowering in serum endotoxin level. Conclusion: QHOL might alter the ratio of enteric flora by increasing anaerobics, a significant lowering of enterogenic endotoxin production and absorption, hence obviously reduced serum endotoxin level was induced which might correlate to the improvement in symptoms and liver damage.