泮托拉唑与奥美拉唑治疗消化性溃疡出血的疗效比较

目的对比泮托拉唑与奥美拉唑治疗消化性溃疡合并上消化道出血的疗效。方法将120例经内镜证实由消化性溃疡引起的上消化道出血患者随机均分成2组，在常规治疗的基础上分别静脉滴注泮托拉唑40mg（A组）或奥美拉唑40mg（B组），每12h用药1次，疗程5d。结果在提高胃内pH方面，A组强于B组（P〈0．05）。A组57例（95．00％）3d内止血，3例（5．00％）4-5d内止血；B组58例（96．67％）3d内止血，2例（3．33％）4-5d内止血。两组总有效率均为100％（P〉0．05）。结论在相同的治疗剂量下，泮托拉唑抑制胃酸的作用比奥美拉唑强，但在控制消化性溃疡出血的疗效方面两药相似。

Comparison of Curative Effects of Pantoprazole and Omeprazolein Treating Peptic Ulcer Bleeding

Objective To compare the curative effects of pantoprazole and omeprazole in treating peptic ulcer bleeding. Methods One hundred and twenty patients with endoscopic proved peptic ulcer bleeding were randomized divided into two groups. Besides the normal medicines, the patients were given intravenous pantoprazole （group A） or omeprazole （group B）40 mg, q 12 h for 5 d. Results The group A was superior to the group B in increasing gastric pH value （P〈0. 05）. Stopping bleeding was within 3 d in 57 cases （95.00%）, 4-5 d in 3 cases （5.00%） for the group A, while for the group B, 58 cases （96. 67% ） within 3 d and 2 cases （3.33%）within 4-5 d. The total effective rate for controlling peptic ulcer bleeding was both 100% in the two groups, without significant difference （P〉 0.05）. Conclusion Pantoprazole is stronger than omeprazole for inhibiting gastric acid in same dosage, but the curative effect of treating peptic ulcer bleeding is similar.