Synthesis and biological activity of indazole-derived HMG-CoA reductase inhibitors |
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| Authors: | Jin-Il Kim Yurngdong Jahng |
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| Affiliation: | 1. College of Pharmacy, Yeungnam University, 712-749, Kyongsan, Korea
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| Abstract: | New hypolipaemic agents, in which substituted indazole nucleus is connected to tetrahydro-4-hydroxy-2H-pyran-2-one by a two-carbon bridge, were designed and synthesized to show significant inhibitory activity against microsomal HMG-CoA reductase in rat liver. |
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| Keywords: | Hypolipaemic Agent HMG-CoA reductase inhibitor Substituted indazoles |
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