| 肺炎链球菌对红霉素的耐药性及耐药表型 |
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| 引用本文： | 王明贵,朱德妹,吴卫红,张婴元,汪复. 肺炎链球菌对红霉素的耐药性及耐药表型[J]. 中华传染病杂志, 2002, 20(2): 71-73 |
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| 作者姓名： | 王明贵 朱德妹 吴卫红 张婴元 汪复 |
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| 作者单位： | 200040,上海,复旦大学华中医院抗生素研究所 |
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| 摘 要： | 目的 调查上海地区肺炎链球菌对红霉素，克林霉素的耐药率及红霉素耐药菌的耐药表型。方法 以琼脂稀释法测定345株肺炎链球菌对红霉素，克林霉素的最低抑菌浓度，以双纸片法测定红霉素耐药菌的耐药表型。结果 肺炎链球菌对红霉素及克林霉素及克林霉素的耐药率分别为53.0%（183/345）及49.6%(171/345)。对红霉素耐药菌中，内在型耐药（cMLS)占90.3%(159/176)，诱导型耐药（iMLS)占5.7%(10/176)，M型耐药占4.0%(7/176)。结论 上海地区肺炎链球菌对红霉素的耐药率高，其耐药表型以cMLS为主。
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| 关 键 词： | 肺炎链球菌 红霉素 克林霉素 药物耐受性 表型 |
| 修稿时间： | 2001-10-18 |
Resistance to erythromycin and resistance phenotypes of Streptococcus pneumoniae |
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| WANG Minggui,ZHU Demei,WU Weihong,et al.. Resistance to erythromycin and resistance phenotypes of Streptococcus pneumoniae[J]. Chinese Journal of Infectious Diseases, 2002, 20(2): 71-73 |
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| Authors: | WANG Minggui ZHU Demei WU Weihong et al. |
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| Affiliation: | WANG Minggui,ZHU Demei,WU Weihong,et al. Institute of Antibiotics,Huashan Hospital,Fudan University,Shanghai 200040,China |
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| Abstract: | Objective To investigate bacterial resistance of Streptococcus pneumoniae against erythromycin and clindamycin, and resistance phenotypes of erythromycin resistant S. pneumoniae. Methods The MICs of erythromycin and clindamycin against 345 strains of S. pneumoniae were tested with agar dilution method, the phenotypes of erythromycin resistant S. pneumoniae were detected by double disc test. Results The resistance rates of S. pneumoniae to erythromycin and clindamycin were 53.0%(183/345) and 49.6%(171/345), respectively. Among erythromycin resistant S. pneumoniae , the percentages of cMLS, iMLS and M phenotype were 90.3% (159/176), 5.7% (10/176) and 4.0%(7/176), respectively. Conclusions The resistance rate of S.pneumoniae against erythromycin is very high in Shanghai. The main phenotype is cMLS. |
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| Keywords: | Streptococcus pneumoniae Erythromycin Clindamycin Drug tolerance Phenotype |
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