| 2型糖尿病患者载脂蛋白B基因型频率分布的初步探讨 |
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| 引用本文： | 郑景晨,俞康,沈飞霞.2型糖尿病患者载脂蛋白B基因型频率分布的初步探讨[J].浙江临床医学,2000,2(1):6-7. |
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| 作者姓名： | 郑景晨 俞康 沈飞霞 |
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| 作者单位： | 郑景晨（325000 温州医学院附属第一医院内分泌科）
俞 康（325000 温州医学院附属第一医院内分泌科）
沈飞霞（325000 温州医学院附属第一医院内医科所） |
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| 摘 要： | 目的：研究载脂蛋白Ｂ（ＡｐｏＢ）基因多态性在本地区２型糖尿病患中的分布及其与血脂的关系。方法：运用聚合酶链反应一限制性片段长度多态性（ＰＣＲ－ＲＦＬＰ）方法检测４１例２型糖病患及６０例正常对照的ＡｐｏＢ基因型。结果：两组Ｘ＾＋和Ｅ＾－等位基因频率分别为０．０８５，０．０１７和－．１１，０．０３３（ｐ〈００１）。糖尿病组血脂总胆固醇（ＣＨ）、甘油三脂（ＴＧ）、低密度脂蛋白脂固醇（ＬＤＬ－ｃｈ）
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| 关 键 词： | 糖尿病 载脂蛋白B基因 高脂血症 PCR－RFLP |
Preliminary Exploration on Relationship between the Polymorphism of Apolipoprotein B(ApoB)Gene and Type 2 Diabetes Mellitus(D M) |
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| Zheng Jingchen.Preliminary Exploration on Relationship between the Polymorphism of Apolipoprotein B(ApoB)Gene and Type 2 Diabetes Mellitus(D M)[J].Zhejiang Clinical Medical Journal,2000,2(1):6-7. |
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| Authors: | Zheng Jingchen |
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| Institution: | Zheng Jingchen et al |
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| Abstract: | Objective: To investigate the relationship getween the polymorphism of apolipoproteinB (ApoB) gene and type 2 diabetes mellitus (DM) and its serum lipid changes. Methods: The ApoB genetype in 41 type 2 diabetes mellitus and 60 normal control subjects were determined by polymerase chain reaction - restriction fragment length polymorphism (PCR - RFLP). Results: The frequencies of X and E- alleies in these two groups were respectively 0. 085, 0. 017 and 0. 11, 0. 033 (P < 0. 01). The levels of serum cholesterol (CH), triglyceride (re) and low density lipopro tein - cholesterol (LDL - ch) in type 2 DM patients were significantly higher than control subjects (p < 0. 01), and the levels of high density lopoprotein - cholesterol (HDL - ch) were lower than control (P < 0. 05). Conclusion: The results suggest that X and E- alleies probably serve as risk factors for type 2 DM and hyperlipidendas. |
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| Keywords: | Type 2 diabetes mellitus Apolipoprotein B gene PCR-RFLP Hyperlipidemia |
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