Osteoimmunology in orthodontic tooth movement |
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| Authors: | C Jiang Z Li H Quan L Xiao J Zhao C Jiang Y Wang J Liu Y Gou S An Y Huang W Yu Y Zhang W He Y Yi Y Chen J Wang |
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| Affiliation: | 1. State Key Laboratory of Oral Diseases, Sichuan University, Chengdu, Sichuan, China;2. Department of Orthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China;3. Qingdao First Sanatorium of Jinan Military Distract of PLA, Qingdao, Shandong, China;4. Department of Prosthodontics, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China;5. Laboratory of Stem Cell Biology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, China |
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| Abstract: | The skeletal and immune systems share a multitude of regulatory molecules, including cytokines, receptors, signaling molecules, and signaling transducers, thereby mutually influencing each other. In recent years, several novel insights have been attained that have enhanced our current understanding of the detailed mechanisms of osteoimmunology. In orthodontic tooth movement, immune responses mediated by periodontal tissue under mechanical force induce the generation of inflammatory responses with consequent alveolar bone resorption, and many regulators are involved in this process. In this review, we take a closer look at the cellular/molecular mechanisms and signaling involved in osteoimmunology and at relevant research progress in the context of the field of orthodontic tooth movement. |
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| Keywords: | osteoimmunology orthodontic tooth movement inflammation osteoblast osteoclast immune factor |
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