蟾酥对豚鼠心脏电生理的影响

目的探讨蟾酥对豚鼠心脏的急性毒性。方法豚鼠一次性ig给予蟾酥125和250 mg·kg-1,记录心电图并监测左心室内压力上升最大速率(dp/dtmax),最大收缩压(Pmax),心率血压乘积(RPP)和心室最小舒张压(Pmin)。结果蟾酥使豚鼠心电图发生显著改变;与正常对照组P-R间期(27.8±5.1)ms相比,蟾酥125和250 mg·kg-1组显著延长,分别为44.5±7.2和(57.1±8.9)ms(P<0.01);蟾酥也引起心电图QRS时程增宽和心率加快;dp/dtmax,Pmax和RPP显著下降以及Pmin显著升高(P<0.05)。与阳性对照地高辛300mg·kg-1相比,蟾酥组P-R间期,QRS时程,dp/dtmax,Pmax,RPP和Pmin无显著性差异,但心率显著增快(P<0.01)。结论蟾酥导致豚鼠心律失常和心功能下降。

Toxic effect of Chansu on cardiac electrophysiology in guinea-pigs

OBJECTIVE 〓To study the effect of Chansu(toad venom, Venenum Bufonis) on the cardiac electrical activity and function. METHODS After guinea-pigs were ig given a single dose of Chansu 125 and 250 mg·kg^-1, electrocardiography and cardiac function were monitored. The cardiac function was evaluated by measuring the maximum rate of rise of left ventricular pressure (dp/dt_max), the maximum systolic pressure (P_max), rate-pressure product (RPP）and the minimum diastolic pressure (P_min). RESULTS Compared with normal control group, the P R interval in Chansu 150 and 250 mg·kg^-1 groups significantly increased from (27.8±5.1) ms to 44.5±7.2 and (57.1±8.9)ms (P<0.01). Chansu also induced wide QRS complex and rapid heart rate, markedly increased P_min(P<0.05), but decreased P_max, RPP and dp/dt_max(P<0.05). No significant difference in P-R interval, QRS complex, dp/dt_max, P_max, RPP and P_min was observed between Chansu and digoxin 300 mg·kg^-1, but Chansu induced faster heart rate than digoxin. CONCLUSION Chansu poisoning can induce arrhythmias and cardiac dysfunction.