OCT 4 immunohistochemistry in postpubertal cryptorchidism |
| |
Authors: | Ivan Krhen Tomislav Kulis Marijana Coric Nikola Knezevic Zvonimir Marekovic Zeljko Kastelan |
| |
Institution: | (1) Department of Surgery, Rajah Muthiah Medical College and Hospital, Annamalai University, Annamalainagar, 608002, India;(2) Department of Urology, Rajah Muthiah Medical College and Hospital, Annamalai University, Annamalainagar, 608002, India |
| |
Abstract: | Patients with cryptorchidism are at an increased risk for germ cell testicular cancer. OCT 4 has been shown to be a sensitive
and specific marker for some types of germ cell testicular cancer. We undertook this study to establish whether OCT 4 immunohistochemistry
is a useful tool in the pathohistologic evaluation of postpubertal patients with cryptorchidism. Seventeen postpubertal patients
underwent orchidectomy for cryptorchidism at our center since 1997. Immunohistochemical staining with OCT 4 was performed
on these samples. Characteristic OCT 4 nuclear staining was positive in two patients. One patient was correctly diagnosed
on previous pathohistological evaluation, while OCT4 immunohistochemical staining revealed previously unidentified intratubular
germ cell neoplasia in the other patient. OCT 4 immunohistochemistry can be useful in diagnosing a testicular germ cell tumor
in patients with cryptorchidism. If we consider a low number of postpubertal patients with cryptorchidism a benefit of immunohistochemical
staining with OCT4, this could favor the use of OCT 4 staining in work-up of cryptorchidism. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|