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Diagnostic value of glypican-3 in serum and liver for primary hepatocellular carcinoma |
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| Authors: | Hui Liu Peng Li Yun Zhai Chun-Feng Qu Li-Jie Zhang Yu-Fen Tan Ning Li Hui-Guo Ding |
| Affiliation: | Hui Liu, Li-Jie Zhang, Department of Pathology, Beijing Youan Hospital, Capital Medical University, Beijing 100069, China;Peng Li, Yun Zhai, Yu-Fen Tan, Ning Li, Hui-Guo Ding, Department of Hepatology and Gastroenterology, Beijing Youan Hospital, Capital Medical University, Beijing 100069, China;Chun-Feng Qu, State Key Laboratory of Molecular Oncology, Cancer Institute/Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China |
| Abstract: | AIM:To evaluate the diagnostic value of glypican-3(GPC3) in serum and liver for primary hepatocellular carcinoma(HCC).METHODS:Serum levels of GPC3 and α-fetoprotein(AFP) were measured in 75 patients with primary HCC and 32 patients with liver cirrhosis.Expression of GPC3 and AFP in 58 HCC and 12 cirrhotic specimens was detected with immunohistochemical staining.RESULTS:When the cut-off value of serum GPC3 was set at 300 ng/L,its sensitivity and specificity for HCC were 47.0% and 93.5%,respectively.Among the... |
| Keywords: | Hepatocellular carcinoma α-fetoprotein Glypican-3 Diagnosis |
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