| α,β-amyrin,a natural triterpenoid ameliorates L-arginine-induced acute pancreatitis in rats |
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| 引用本文： | Caroline,Mouro,Melo Karine,Maria Martins,Bezerra Carvalho,Julliana Catharina,de Sousa,Neves Talita,Cavalcante Morais,Vietla Satyanarayana,Rao,Flávia,Almeida Santos,Gerly Anne,de Castro,Brito Mariana,Helena Chaves.α,β-amyrin,a natural triterpenoid ameliorates L-arginine-induced acute pancreatitis in rats[J].世界胃肠病学杂志(英文版),2010,16(34):4272-4280. |
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| 作者姓名： | Caroline Mouro Melo Karine Maria Martins Bezerra Carvalho Julliana Catharina de Sousa Neves Talita Cavalcante Morais Vietla Satyanarayana Rao Flávia Almeida Santos Gerly Anne de Castro Brito Mariana Helena Chaves |
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| 作者单位： | Department of Physiology and Pharmacology Biomedical Institute of Brazilian Semiarid Faculty of Medicine Federal University of Ceará Department of Morphology Department of Organic and Inorganic Chemistry Federal University of Piauí |
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| 基金项目： | Supported by Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), Brazil |
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| 摘 要： | AIM: To study the benef icial effects of triterpene α,β-amyrin and the underlying mechanisms in an experimental pancreatitis model. METHODS: Acute pancreatitis was induced in five groups of rats (n = 8) by L-arginine (2 × 2.5 g/kg, intraperitoneal, 1 h apart) and 1 h later, they received a single oral dose of α,β-amyrin (10, 30 and 100 mg/kg),methylprednisolone (30 mg/kg) and vehicle (3% Tween 80). A saline (0.9% NaCl) treated group served as a normal control. Efficacy was assessed at 24 h by determination ...
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| 关 键 词： | Acute pancreatitis L-arginine Cytokines Lipid peroxidation α β-amyrin |
| 收稿时间： | 2010 Apr 30 |
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