Ancistroealaines A and B, two new bioactive naphthylisoquinolines, and related naphthoic acids from Ancistrocladus ealaensis |
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| Authors: | Bringmann G Hamm A Günther C Michel M Brun R Mudogo V |
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| Institution: | Institut für Organische Chemie der Universit?t, Am Hubland, D-97074 Würzburg, Germany. bringman@chemie.uni-wuerzburg.de |
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| Abstract: | Two new 5,8'-coupled naphthylisoquinoline alkaloids, ancistroealaines A (1) and B (2), eleutherolic acid (3), and two naphthoic acids, ancistronaphthoic acid A (4) and B (5), have been isolated from Ancistrocladus ealaensis. Their structures were determined by spectroscopic, chemical, and chiroptical methods. Ancistroealaine A (1) exhibited activity against Leishmania donovani and Trypanosoma cruzi in vitro. |
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