Adenocarcinoma of the colon with neuroendocrine features and secretory diarrhea |
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Authors: | Edward A Lew MD Klaus J Lewin MD Thomas Zarchy MD Joseph R Pisegna MD |
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Institution: | CURE, Department of Medicine, UCLA Medical Center, Los Angeles, California, USA. |
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Abstract: | We report the case of a 63-yr-old man who had severe secretory diarrhea associated with colonic adenocarcinoma, with a prominent signet ring cell component and numerous endocrine cells as demonstrated by positive chromogranin-A staining. Improvement in the secretory diarrhea by the somatostatin analog Sandostatin suggested that the diarrhea was related to a functional neuroendocrine tumor within the colonic tumor, the first case to be reported in the literature. |
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