曲美他嗪对冠状动脉慢性完全闭塞病变经皮冠状动脉介入治疗术后心功能的影响

目的探讨曲美他嗪对冠状动脉慢性完全闭塞病变患者经皮冠状动脉介入治疗(PCI)术后心功能的影响。方法经冠状动脉造影确诊冠状动脉慢性完全闭塞病变患者90例,其中43例行PCI术,术后分为两组:A组23例,B组20例;未行PCI术47例,分为两组:C组25例,D组22例。A组、C组曲美他嗪口服,20mg,3次/d;B组、D组不服用曲美他嗪。4组均给予冠心病常规治疗。治疗跟踪观察12个月,其中A、B、C组各有1例、D组有2例死亡,剔除。比较4组治疗12个月前后超声心动图变化。结果A、B和C组治疗前后心功能均有明显改善,各组心功能超声学参数治疗后与治疗前比较差异有统计学意义(P0.05);A组治疗后的心功能较B组治疗后的心功能改善更明显,A组治疗后心功能超声学参数与B组治疗后比较差异有统计学意义(P0.05)。结论曲美他嗪能进一步改善冠状动脉慢性完全闭塞病变患者PCI术后的心功能。

Effects of trimetazidine on heart function in patients with chronic total occlusions of coronary artery after percutaneous coronary intervention

Objective To investigate the effects of trimetazidine ( TMZ) on heart function in patients with chronic total occlusions after percutaneous coronary intervention(PCI). Methods Ninety patients with chronic total occlusions of coronary were divided into four groups :group A ( n =23),group B( n =20),group C( n = 25),group D( n = 22). All groups were treated with conventional therapy. Of all groups,A and B were undergone precutaneous coronary intervention,A and C were treated with TMZ therapy group for twelve m...