Trends in the Frequency of HLA DR-DQ Haplotypes Among Children and Adolescents with Type 1 Diabetes Mellitus in the Southeast Region of Turkey |
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| Authors: | Mehmet Keskin Ay?e Aygün Sacide Pehlivan ?zlem Keskin Y?lmaz Kor Ay?e Balat Yavuz Co?kun |
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| Affiliation: | 1 Gaziantep University Faculty of Medicine, Department of Pediatric Endocrinology and Metabolisms, Gaziantep, Turkey ;2 Gaziantep University Faculty of Medicine, Department of Pediatrics, Gaziantep, Turkey ;3 Gaziantep University Faculty of Medicine, Department of Medical Biology, Gaziantep, Turkey |
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| Abstract: | Objective: The aim of this study was to determine the frequency of HLA DR-DQ haplotypes in children with type 1 diabetes mellitus (T1DM) in the Southeast Region of Turkey.Methods: Eighty children and adolescents with T1DM and eighty control subjects participated in the study. HLA-DR, DQ was typed using polymerase chain reaction and sequence-specific priming technique.Results: HLA DRB1*03 allele was significantly more common in patients than in control subjects. HLA DRB1*11, HLA DRB1*13 and HLA DRB1*14 allele frequencies were significantly lower in patients than in controls. DQB1*02 allele was more common in patients, whereas DQB1*03 allele was more frequent in control subjects. HLA DRB1*03-DQB1*02 haplotype was more frequently observed among patients.Conclusion: These results confirm the similar potential trends in the frequency distribution of HLA susceptibility genes with T1DM previously observed in Turkey and in other Caucasian populations. Conflict of interest:None declared. |
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| Keywords: | type 1 diabetes mellitus HLA DR-DQ haplotype allele children Autoimmunity |
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