| 氨噻肟类青霉素衍生物的定量构效关系 |
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| 引用本文： | 朱佳玲,李巧云,沈振武. 氨噻肟类青霉素衍生物的定量构效关系[J]. 中国抗生素杂志, 1990, 0(6) |
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| 作者姓名： | 朱佳玲 李巧云 沈振武 |
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| 作者单位： | 上海医科大学药学院 上海200032(朱佳玲，李巧云)，中国科学院上海有机化学研究所 上海200032(沈振武) |
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| 摘 要： | 用分子连接性的方法建立的氨噻肟类青霉素衍生物定量构效关系方程式,对药物分子结构进行定量判断。找出其最适一阶分子连接性指数~1X~v的范围,预示了该类化合物中其余同源物的活性。
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| 关 键 词： | 氨噻肟类青霉素 分子连接性 分子连接性性指数 构效关系 |
THE QUANTITATIVE STRUCTURE ACTIVITY RELATIONSHIPS OF AMINOTHIAZO PENICILLIN DERIVATIVES |
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| Zhu Jia-ling and Li Qiao-yun. THE QUANTITATIVE STRUCTURE ACTIVITY RELATIONSHIPS OF AMINOTHIAZO PENICILLIN DERIVATIVES[J]. Chinese Journal of Antibiotics, 1990, 0(6) |
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| Authors: | Zhu Jia-ling and Li Qiao-yun |
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| Abstract: | The equations of quantitative structure- activity relationships of am-inothiazo penicillin derivatives have been established by the method of molecular connectivity and the molecular structures of medicines are determined quantitatively. The most suitable range of one order molecular connectivity index has been found and the activities of other similar compounds are predicted. |
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| Keywords: | Aminothtazo penicilin Molecular connectivity Molecular connectivity index Structure-activity relationship |
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