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Robust Effect of Hepatic Arterial Infusion Chemotherapy and Radiation Therapy on Hepatocellular Carcinoma Arising from Fontan-associated Liver Disease |
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| Authors: | Hiroyuki Suzuki Takashi Niizeki Tomotake Shirono Yusuke Koteda Yoshinao Kinjyo Naohisa Mizukami Makoto Koda Satoshi Ota Masahito Nakano Shusuke Okamura Hideki Iwamoto Shigeo Shimose Yu Noda Naoki Kamachi Akira Kajiwara Kenji Suda Jun Akiba Hirohisa Yano Ryoko Kuromatsu Hironori Koga Takuji Torimura |
| Affiliation: | 1.Division of Gastroenterology, Department of Medicine, Kurume University School of Medicine, Japan; 2.Department of Pediatrics and Child Health, Kurume University School of Medicine, Japan; 3.Department of Pathology, Kurume University School of Medicine, Japan; 4.Kumamoto Radiosurgery Clinic, Japan; 5.Iwamoto Internal Medicine Clinic, Japan |
| Abstract: | Fontan-associated liver disease (FALD) caused by long-term systemic venous congestion following the Fontan procedure may eventually lead to hepatocellular carcinoma (HCC). Treatment strategies for HCC due to FALD (FALD-HCC) remain unclear. We herein report a 35-year-old man with FALD-HCC that was well controlled by 3 cycles of continuous infusion of 5-fluorouracil and low-dose cisplatin (low-dose FP therapy) combined with 60 Gy of radiation therapy. However, the patient ultimately died of extrahepatic metastases. A pathological autopsy revealed more than 90% necrosis in the primary HCC lesion. This case suggests that low-dose FP therapy might be effective in FALD-HCC. |
| Keywords: | Fontan-associated liver disease hepatocellular carcinoma low-dose FP therapy radiation therapy |