| 丝裂原活化蛋白激酶激活的蛋白激酶2在心血管系统中的作用 |
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| 引用本文： | 陈坤,左中,赵蕾. 丝裂原活化蛋白激酶激活的蛋白激酶2在心血管系统中的作用[J]. 中国动脉硬化杂志, 2019, 27(5): 456-460 |
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| 作者姓名： | 陈坤 左中 赵蕾 |
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| 作者单位： | 重庆医科大学附属第一医院心血管内科;重庆医科大学脂糖代谢性疾病重庆市重点实验室脂质研究中心 |
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| 摘 要： | 心血管疾病的发生发展与慢性炎症有关。p38丝裂原活化蛋白激酶(MAPK)介导的信号通路在心血管细胞炎症、增殖、分化、迁移和代谢中起着重要作用。抑制p38MAPK可有效抑制炎症介质的表达,由于p38抑制剂在安全性方面不可接受,故研究其下游底物是很有必要的。丝裂原活化蛋白激酶激活的蛋白激酶2(MK2)是p38MAPK重要的下游底物且参与了心血管疾病的发生发展。因此抑制MK2的活性在心血管疾病的治疗及预防中具有重大的临床意义。文章主要对MK2的结构功能和在心血管疾病中的作用展开综述。
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| 关 键 词： | 丝裂原活化蛋白激酶激活的蛋白激酶2 心血管系统 心血管疾病 |
| 收稿时间： | 2018-05-09 |
| 修稿时间： | 2018-08-30 |
Role of mitogen activated protein kinase activated protein kinase 2 in cardiovascular system |
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| CHEN Kun,ZUO Zhong and ZHAO Lei. Role of mitogen activated protein kinase activated protein kinase 2 in cardiovascular system[J]. Chinese Journal of Arteriosclerosis, 2019, 27(5): 456-460 |
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| Authors: | CHEN Kun ZUO Zhong ZHAO Lei |
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| Affiliation: | Department of Cardiology, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China,Department of Cardiology, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China and Key Laboratory of Metabolism on Lipid and Glucose, Center for Lipid Research, Chongqing Medical University, Chongqing 400016, China |
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| Abstract: | The development of cardiovascular disease is related to chronic inflammation. p38 mitogen activated protein kinase (p38MAPK) mediated signaling pathway plays an important role in cardiovascular cell inflammation, proliferation, differentiation, migration and metabolism. Inhibition of p38MAPK can effectively inhibit the expression of inflammatory mediators. In terms of safety, p38 inhibitors are unacceptable and it is necessary to study the downstream substrate. Mitogen-actitated protein kinase actitaved protein kinase 2 (MK2) is an important downstream substrate of p38MAPK and is involved in the development of cardiovascular diseases. Therefore, inhibition of MK2 activity is of great clinical significance in the treatment and prevention of cardiovascular diseases. This article mainly reviews the structure and function of MK2 and its role in cardiovascular diseases. |
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| Keywords: | mitogen-actitated protein kinase actitaved protein kinase 2 cardiovascular system cardiovascular disease |
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