| 中性粒细胞明胶酶相关脂质运载蛋白与心血管疾病的关系 |
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| 引用本文： | 张英,刘晓腾,金凤表,刘秋梅,刘慧卿,高宇,侯瑞田. 中性粒细胞明胶酶相关脂质运载蛋白与心血管疾病的关系[J]. 中国动脉硬化杂志, 2019, 27(10): 915-920 |
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| 作者姓名： | 张英 刘晓腾 金凤表 刘秋梅 刘慧卿 高宇 侯瑞田 |
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| 作者单位： | 承德医学院附属医院心脏电生理科 |
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| 基金项目： | 承德市技术研究与发展计划项目(201801A026) |
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| 摘 要： | 中性粒细胞明胶酶相关脂质运载蛋白(NGAL)也被称为Lcn2,或癌基因24p3,是成熟嗜中性粒细胞特异性颗粒中储存的明胶酶复合的糖蛋白,也由其他细胞类型产生,包括心肌细胞。NGAL是急性肾损伤的早期生物标志物。最近发现NGAL可能是主要不良心血管事件和死亡率的独立预测因子,但关于NGAL与心血管疾病(CVD)的关系尚未达成一致,文章就NGAL与冠心病、高血压、心力衰竭的关系及NGAL与心血管疾病相关靶向治疗做一综述。
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| 关 键 词： | NGAL 冠心病 高血压 心力衰竭 靶向治疗 |
| 收稿时间： | 2018-12-04 |
| 修稿时间： | 2019-02-21 |
The relationship between neutrophil gelatinase-associated lipocalin and cardiovascular diseases |
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| ZHANG Ying,LIU Xiaoteng,JIN Fengbiao,LIU Qiumei,LIU Huiqing,GAO Yu and HOU Ruitian. The relationship between neutrophil gelatinase-associated lipocalin and cardiovascular diseases[J]. Chinese Journal of Arteriosclerosis, 2019, 27(10): 915-920 |
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| Authors: | ZHANG Ying LIU Xiaoteng JIN Fengbiao LIU Qiumei LIU Huiqing GAO Yu HOU Ruitian |
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| Affiliation: | Department of Cardioelectrophysiology, the Affiliated Hospital of Chengde Medical University, Chengde, Hebei 067000, China,Department of Cardioelectrophysiology, the Affiliated Hospital of Chengde Medical University, Chengde, Hebei 067000, China,Department of Cardioelectrophysiology, the Affiliated Hospital of Chengde Medical University, Chengde, Hebei 067000, China,Department of Cardioelectrophysiology, the Affiliated Hospital of Chengde Medical University, Chengde, Hebei 067000, China,Department of Cardioelectrophysiology, the Affiliated Hospital of Chengde Medical University, Chengde, Hebei 067000, China,Department of Cardioelectrophysiology, the Affiliated Hospital of Chengde Medical University, Chengde, Hebei 067000, China and Department of Cardioelectrophysiology, the Affiliated Hospital of Chengde Medical University, Chengde, Hebei 067000, China |
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| Abstract: | Neutrophil gelatinase-associated lipocalin (NGAL), also known as Lcn2 (lipocalin 2), or oncogene 24p3, is a gelatinase complex stored in mature neutrophil-specific particles. Glycoproteins are also produced by other cell types, including cardiomyocytes. NGAL is an early biomarker of acute kidney injury. Recently, NGAL has been found to be an independent predictor of major adverse cardiovascular events and mortality, but the relationship between NGAL and cardiovascular disease (CVD) has not been agreed. This article reviews the relationship between NGAL and coronary heart disease, hypertension and heart failure, and the targeted therapy of NGAL and CVD. |
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| Keywords: | NGAL coronary heart disease hypertension heart failure targeted therapy |
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