微小RNA在主动脉夹层中差异性表达与发病机制的研究进展

主动脉夹层(AD)是临床一种死亡率极高的心血管危急重症,具有起病急骤、进展快、表现复杂多样、病程凶险、死亡率高、预后差等特点。虽然目前AD的具体发病机制尚未完全阐明,但近年来发现,微小RNA(miRNA)在许多心血管疾病的发生及发展过程中起着重要作用。通过应用基因芯片技术分析等相关研究发现,AD患者组织与正常主动脉组织的一些miRNA存在显著的差异性表达,这显然有助于AD的诊断。诸多研究表明miRNA在AD的发病机制及疾病诊断中可能扮演着重要角色。本文就miRNA在AD的差异性表达与发病机制的研究进展作一综述。

Research progress on differential expression of microRNAs and pathogenesis in aortic dissection

Aortic dissection (AD) is a serious cardiovascular disease with high mortality rate. It has the characteristics of rapid onset, rapid progress, complex and diverse manifestations, dangerous course, high mortality and poor prognosis. Although the specific pathogenesis of AD has not been fully elucidated, in recent years, microRNA (miRNA) has been found to play an important role in the occurrence and development of many cardiovascular diseases. Through the application of gene chip technology analysis and other related studies, it is found that there are significant differences in the expression of some microRNAs between AD patients and normal aortic tissues, which obviously contribute to the diagnosis of AD. Many studies have shown that miRNAs may play an important role in the pathogenesis and diagnosis of AD. This article reviews the research progress on differential expression and pathogenesis of miRNAs in AD.