微观结构在易损斑块进展中的作用

急性冠状动脉综合征常常导致严重的心血管事件,而冠状动脉粥样硬化斑块破裂是绝大多数急性冠状动脉综合征发生的原因,因此检测高破裂风险的易损斑块,对筛选和干预急性冠状动脉综合征具有重要意义。随着研究的不断进展,易损斑块内的一些微观结构如斑块内新生血管、微小钙化、胆固醇结晶,在易损斑块的进展中起到重要的作用。因此,本文以易损斑块内最常见的3种微观结构为重点,综述斑块内微观结构在易损斑块进展中的作用。

The role of microstructures in the progression of vulnerable plaque

Acute coronary syndrome often leads to severe cardiovascular events, and the cause of most acute coronary syndromes is coronary atherosclerotic plaque rupture. Therefore, the detection of vulnerable plaque with high risk of rupture is of great significance for the screening and intervention of acute coronary syndrome. Vulnerable plaques have some microstructures such as neovascularization, spotty calcification and cholesterol crystal, which play important roles in the progression and pathogenesis of vulnerable plaques.