| 血清N末端B型利钠肽原和同型半胱氨酸联合检测对冠状动脉病变的评估价值 |
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| 引用本文： | 白敏,陈向红,郭照军,陈磊,王超,吴曾繁,王雅纯. 血清N末端B型利钠肽原和同型半胱氨酸联合检测对冠状动脉病变的评估价值[J]. 中国动脉硬化杂志, 2019, 27(3): 241-246 |
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| 作者姓名： | 白敏 陈向红 郭照军 陈磊 王超 吴曾繁 王雅纯 |
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| 作者单位： | 海南医学院第二附属医院心血管内科;海南医学院第一附属医院老年科 |
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| 摘 要： | 目的探讨血清N末端B型利钠肽原(NT-proBNP)和同型半胱氨酸(Hcy)联合检测评估冠心病患者冠状动脉斑块性状的价值及相关程度。方法 188例冠心病患者按照临床分型分为2组:稳定型心绞痛(SAP)组(n=106)、急性冠状动脉综合征(ACS)组(n=82);选择同时期接受冠状动脉造影检查结果正常者为对照组(n=90)。测定血清NT-proBNP、Hcy及高敏C反应蛋白(hs-CRP)水平。根据冠状动脉造影结果计算Gensini积分;采用血管内超声检测斑块成分指标。应用Pearson相关分析NT-proBNP、Hcy水平与Gensini积分及斑块成分指标的相关性。应用Logistic回归分析NT-proBNP、Hcy水平与易损性斑块的关系。应用受试者工作特征(ROC)曲线下面积(AUC)分析NT-proBNP、Hcy预测易损性斑块的价值。结果 3组间NT-proBNP、Hcy与hs-CRP浓度均存在显著差异(P0.05),且均为ACS组SAP组对照组(均P0.05)。ACS组Gensini积分、坏死核心(NC)比例、血管重塑指数(VRI)、斑块偏心指数(PEI)均显著高于SAP组(P0.05)。NT-proBNP、Hcy水平与Gensini积分及斑块NC比例、VRI、PEI呈正相关(均P0.05)。多元Logistic回归分析显示,NT-proBNP、Hcy血清水平是冠心病患者易损性斑块的独立危险因素(均P0.05)。NT-proBNP、Hcy预测冠状动脉易损性斑块的AUC分别为0.764(95%CI 0.729～0.803,P=0.021)、0.779(95%CI 0.742～0.814,P=0.015);两者联合预测冠状动脉易损性斑块的AUC为0.886(95%CI 0.823～0.951,P=0. 004)。结论血清NT-proBNP、Hcy联合检测可有效评估冠心病患者冠状动脉斑块病变性状。
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| 关 键 词： | N末端B型利钠肽原 同型半胱氨酸 冠心病 评估价值 |
| 收稿时间： | 2018-01-22 |
| 修稿时间： | 2018-05-09 |
Evaluation value of combined detection of serum N-terminal pro-B-type natriuretic peptide and homocysteine for coronary artery disease |
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| BAI Min,CHEN Xianghong,GUO Zhaojun,CHEN Lei,WANG Chao,WU Zengfan and WANG Yachun. Evaluation value of combined detection of serum N-terminal pro-B-type natriuretic peptide and homocysteine for coronary artery disease[J]. Chinese Journal of Arteriosclerosis, 2019, 27(3): 241-246 |
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| Authors: | BAI Min CHEN Xianghong GUO Zhaojun CHEN Lei WANG Chao WU Zengfan WANG Yachun |
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| Affiliation: | Department of Cardiology, the Second Affiliated Hospital of Hainan Medical College, Haikou, Hainan 570311, China,Department of Cardiology, the Second Affiliated Hospital of Hainan Medical College, Haikou, Hainan 570311, China,Department of Cardiology, the Second Affiliated Hospital of Hainan Medical College, Haikou, Hainan 570311, China,Department of Cardiology, the Second Affiliated Hospital of Hainan Medical College, Haikou, Hainan 570311, China,Department of Cardiology, the Second Affiliated Hospital of Hainan Medical College, Haikou, Hainan 570311, China,Department of Cardiology, the Second Affiliated Hospital of Hainan Medical College, Haikou, Hainan 570311, China and Department of Geriatrics, the First Affiliated Hospital of Hainan Medical College, Haikou, Hainan 570102, China |
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| Abstract: | |
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| Keywords: | N-terminal pro-B-type natriuretic peptide homocysteine coronary heart disease evaluation value |
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