| 虎杖苷通过激活Nrf2/HO-1信号通路减轻大鼠急性心肌梗死后心肌细胞损伤 |
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| 引用本文： | 雷斌,唐玲,张亮,赵航天,朱晓丽,李家燕. 虎杖苷通过激活Nrf2/HO-1信号通路减轻大鼠急性心肌梗死后心肌细胞损伤[J]. 中国动脉硬化杂志, 2019, 27(9): 757-763 |
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| 作者姓名： | 雷斌 唐玲 张亮 赵航天 朱晓丽 李家燕 |
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| 作者单位： | 河南科技大学第三附属医院洛阳东方医院心内科二病区 |
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| 摘 要： | 目的研究虎杖苷对大鼠急性心肌梗死(AMI)后心肌细胞损伤的保护作用及分子机制。方法 SD雄性大鼠随机分为Sham组、AMI组、虎杖苷组、虎杖苷+ZnPP组。后3组通过左冠状动脉前降支结扎的方式建立AMI模型。虎杖苷为每天40 mg/kg灌胃,血红素加氧酶1(HO-1)抑制剂Zn PP为每天20 mg/kg腹腔注射。造模后第8天,检测各组心功能超声指标左心室射血分数(LVEF)、左室内压力变化最大上升和下降速率(±dp/dtmax)、血清心肌损伤指标、心肌梗死面积、心肌氧化应激指标及核因子E2相关因子2(Nrf2)/HO-1表达情况。结果与Sham组比较,AMI组LVEF、+dp/dtmax、-dp/dtmax及心肌超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)的含量均明显降低,心肌梗死面积及血清乳酸脱氢酶(LDH)、磷酸肌酸激酶(CK)、磷酸肌酸激酶同工酶(CK-MB)含量及心肌丙二醛(MDA)的含量及Nrf-2、HO-1的表达水平均明显增加(P0. 05)。与AMI组比较,虎杖苷组LVEF、+dp/dtmax、-dp/dtmax及心肌SOD、GSH-Px的含量及Nrf-2、HO-1的表达水平均明显升高,心肌梗死面积及血清LDH、CK、CK-MB含量及心肌MDA的含量均明显降低(P0. 05)。与虎杖苷组比较,虎杖苷+ZnPP组LVEF、+dp/dtmax、-dp/dtmax及心肌SOD、GSH-Px的含量均明显降低,心肌梗死面积及血清LDH、CK、CK-MB含量及心肌MDA的含量均明显增加(P0. 05)。结论虎杖苷能够减轻大鼠急性心肌梗死后心肌细胞损伤,该效应可能由Nrf2/HO-1通路的激活介导。
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| 关 键 词： | 虎杖苷 急性心肌梗死 核因子E2相关因子2 血红素加氧酶1 信号通路 氧化应激 |
| 收稿时间： | 2019-02-13 |
| 修稿时间： | 2019-05-24 |
Polydatin attenuating myocardial cell injury after acute myocardial infarction in rats through activating Nrf2/HO-1 signaling pathway |
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| LEI Bin,TANG Ling,ZHANG Liang,ZHAO Hangtian,ZHU Xiaoli and LI Jiayan. Polydatin attenuating myocardial cell injury after acute myocardial infarction in rats through activating Nrf2/HO-1 signaling pathway[J]. Chinese Journal of Arteriosclerosis, 2019, 27(9): 757-763 |
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| Authors: | LEI Bin TANG Ling ZHANG Liang ZHAO Hangtian ZHU Xiaoli LI Jiayan |
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| Affiliation: | Department of Cardiology, the Third Affiliated Hospital of Henan University of Science and Technology, Hospital of Luoyang Dongfang, Luoyang, Henan 471003, China,Department of Cardiology, the Third Affiliated Hospital of Henan University of Science and Technology, Hospital of Luoyang Dongfang, Luoyang, Henan 471003, China,Department of Cardiology, the Third Affiliated Hospital of Henan University of Science and Technology, Hospital of Luoyang Dongfang, Luoyang, Henan 471003, China,Department of Cardiology, the Third Affiliated Hospital of Henan University of Science and Technology, Hospital of Luoyang Dongfang, Luoyang, Henan 471003, China,Department of Cardiology, the Third Affiliated Hospital of Henan University of Science and Technology, Hospital of Luoyang Dongfang, Luoyang, Henan 471003, China and Department of Cardiology, the Third Affiliated Hospital of Henan University of Science and Technology, Hospital of Luoyang Dongfang, Luoyang, Henan 471003, China |
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