| 小分子药物调控胆固醇逆向转运机制的研究进展 |
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| 引用本文： | 朱海波. 小分子药物调控胆固醇逆向转运机制的研究进展[J]. 中国动脉硬化杂志, 2019, 27(2): 93-100 |
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| 作者姓名： | 朱海波 |
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| 作者单位： | 天然药物活性物质与功能国家重点实验室新药作用机制研究与药效学评价北京重点实验室中国医学科学院北京协和医学院药物研究所 |
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| 基金项目： | 国家自然科学基金重大研究计划培育项目(91539126);中国医学科学院医学与健康科技创新工程重大协同创新项目(2016-I2M-1-009) |
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| 摘 要： | 本文从小分子药物调控胆固醇逆向转运机制的视角,介绍胆固醇逆向转运关键蛋白参与小分子药物调控胆固醇外流和脂质代谢机制的最新研究进展,探讨不同化学结构类型小分子药物对介导胆固醇逆向转运不同药靶蛋白表达的影响,从药理学的研究角度提供开展胆固醇逆向转运相关研究新的思维模式。
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| 关 键 词： | 小分子药物 胆固醇逆向转运 作用机制 分子药理 |
| 收稿时间： | 2018-05-15 |
| 修稿时间： | 2018-06-19 |
Advances in mechanism of small molecule drugs in regulating reverse cholesterol transport |
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| ZHU Haibo. Advances in mechanism of small molecule drugs in regulating reverse cholesterol transport[J]. Chinese Journal of Arteriosclerosis, 2019, 27(2): 93-100 |
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| Authors: | ZHU Haibo |
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| Affiliation: | State Key Laboratory for Bioactive Substances and Functions of Natural Medicines & Beijing Key Laboratory of New Drug Mechanisms and Pharmacological Evaluation Study & Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China |
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| Abstract: | This paper, from the perspective of small molecule drugs regulating reverse cholesterol transport mechanism, introduces the latest research progress in the role of RCT key proteins in the regulation of cholesterol efflux and lipid metabolism by small molecule drugs, and explore the role of small molecule drugs with different chemical structures in mediating the expression of different drug target proteins in RCT. The purpose of this study is, from a point of view of pharmacology, to provide a new thinking mode for RCT related research. |
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| Keywords: | small molecule drugs reverse cholesterol transport action mechanism molecular pharmacology |
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