外泌体中的微小RNA在动脉粥样硬化中的作用

动脉粥样硬化(As)是指血管在各种危险因子的作用下引发的一种慢性炎症性疾病,是心脑血管病的主要病理基础,近些年As的发病率日趋增高,但其发病机制依旧不明。因此,探讨As的发病机制,对于早期发现和治疗该疾病具有重要意义。外泌体作为细胞间通讯的重要媒介在As的进程中扮演着重要角色。微小RNA(miRNA)作为关键的信号传导和分子调控途径参与As的形成。所以本文对外泌体内含物miRNA在As的形成与发展过程中所起的调控作用进行综述。

Role of micro RNA inexosomes in atherosclerosis

Atherosclerosis (As) is a chronic inflammatory disease triggered by various risk factors and is the main pathological basis of cardiovascular and cerebrovascular diseases. In recent years, the incidence of As has been increasing, but its pathogenesis remains unknown. Therefore, it is of great significance to explore the pathogenesis of As for early detection and treatment of the disease. As an important mediator of intercellular communication, exosomes plays an important role in the process of As. Micro RNA (miRNA) is involved in the formation of As as a key signal transduction and molecular regulation pathway. Therefore, this article reviews the regulatory role of exosomes inclusion miRNA in the formation and development of As.