| 冠心病患者单核细胞/淋巴细胞比率与冠状动脉病变严重程度的相关性分析 |
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| 引用本文： | 柳强,胡有志,薛雪. 冠心病患者单核细胞/淋巴细胞比率与冠状动脉病变严重程度的相关性分析[J]. 中国动脉硬化杂志, 2019, 27(10): 868-873 |
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| 作者姓名： | 柳强 胡有志 薛雪 |
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| 作者单位： | 湖北省中医院心内科;湖北省中医药研究院心内科;湖北中医药大学附属医院心内科;湖北中医药大学第一临床学院内科教研室 |
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| 基金项目： | 国家中医药管理局全国名老中医药专家传承工作室建设项目(财社[2013]135号) |
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| 摘 要： | 目的探讨冠心病患者单核细胞/淋巴细胞比率(MLR)与冠状动脉病变严重程度的相关性及其预测价值。方法选取2018年1月至12月在湖北省中医院花园山院区心内科住院并行冠状动脉造影的患者203例作为研究对象。将161例确诊冠心病的患者按照冠状动脉病变严重程度(Gensini评分)分为轻度病变组、中度病变组及重度病变组;再将161例冠心病患者按照MLR三分位数分成3组。对照组42例,冠状动脉造影显示冠状动脉正常或狭窄程度小于50%。用Logistic逐步回归方法及受试者工作特征曲线(ROC)分析冠心病患者MLR与冠状动脉病变严重程度的相关性及其预测价值。结果①MLR三分位组间比较,第2三分位组、第3三分位组冠状动脉病变积分较第1三分位组明显升高(P=0.022,P=0.001)。②Spearman相关分析显示,MLR水平与冠心病患者冠状动脉病变程度呈正相关(r=0.281,P0.01);Kendall相关分析亦显示二者呈正相关(r=0.188,P0.01)。③Logistic逐步回归分析显示吸烟史、高龄、MLR、载脂蛋白B是冠心病发病的独立危险因素,载脂蛋白A1则是冠心病的保护性因素。④ROC曲线分析显示,MLR的曲线下面积为0.709(95%CI:0.621～0.797)。当MLR临界值取0.186时,其诊断冠心病效能最高,敏感性为82.6%,特异性为50.0%。结论炎症在冠心病的发病过程中发挥了至关重要的作用,MLR作为独立危险因素之一,对冠心病有预测价值。
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| 关 键 词： | 冠心病 单核细胞/淋巴细胞比率 冠状动脉病变程度 |
| 收稿时间： | 2019-03-06 |
| 修稿时间： | 2019-04-28 |
Analysis of correlation between monocyte to lymphocyte ratio and lesion severity of coronary artery in patients with coronary heart disease |
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| LIU Qiang,HU Youzhi and XUE Xue. Analysis of correlation between monocyte to lymphocyte ratio and lesion severity of coronary artery in patients with coronary heart disease[J]. Chinese Journal of Arteriosclerosis, 2019, 27(10): 868-873 |
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| Authors: | LIU Qiang HU Youzhi XUE Xue |
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| Affiliation: | Department of Cardiology, Hubei Provincial Hospital of Traditional Chinese Medicine, Wuhan, Hubei 430061, China;Department of Cardiology, Hubei Provincial Academy of Traditional Chinese Medicine, Wuhan, Hubei 430074, China;Department of Cardiology, Affiliated Hospital of Hubei University of Traditional Chinese Medicine, Wuhan, Hubei 430061, China,Department of Cardiology, Hubei Provincial Hospital of Traditional Chinese Medicine, Wuhan, Hubei 430061, China;Department of Cardiology, Hubei Provincial Academy of Traditional Chinese Medicine, Wuhan, Hubei 430074, China;Department of Cardiology, Affiliated Hospital of Hubei University of Traditional Chinese Medicine, Wuhan, Hubei 430061, China and Teaching and Research Department of Internal Medicine, First Clinical College, Hubei University of Traditional Chinese Medicine, Wuhan, Hubei 430061, China |
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| Abstract: | |
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| Keywords: | coronary heart disease monocyte to lymphocyte ratio lesion severity of coronary artery |
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