| 铁超载与肝细胞癌关系的研究进展 |
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| 引用本文： | 赵睿. 铁超载与肝细胞癌关系的研究进展[J]. 临床肝胆病杂志, 2011, 27(6): 670-673 |
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| 作者姓名： | 赵睿 |
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| 作者单位： | 兰州大学第二医院肝病科,甘肃省消化系肿瘤重点实验室,兰州730030 |
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| 基金项目： | 甘肃省自然科学基金(1010RJZA087) |
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| 摘 要： | 肝细胞癌（HCC）的发生与多种因素有关。早期的流行病学研究显示非洲人群饮食中铁过量与HCC发生相关,继而研究发现许多与铁沉积相关的疾病如遗传性血色素沉积症（HH）、丙型病毒性肝炎、非酒精性脂肪性肝病（NAFLD）等在发展过程中均有发生HCC的可能性,提示铁超载可能在其中发挥着直接或间接的作用。现认为铁超载的发生与基因突变、铁代谢相关基因蛋白的异常表达、氧化应激反应、免疫紊乱、促进癌细胞生长等因素有关。本文就铁超载与HCC的相关研究现状作一综述
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| 关 键 词： | 肝肿瘤 铁 |
Recent progress in relationship between iron overload and hepatocellular carcinoma |
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| ZHAO Rui. Recent progress in relationship between iron overload and hepatocellular carcinoma[J]. Chinese Journal of Clinical Hepatology, 2011, 27(6): 670-673 |
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| Authors: | ZHAO Rui |
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| Affiliation: | ZHAO Rui,ZHANG Ling-yi.(Department of Liver Disease,the Second Hospital of Lanzhou University,Lanzhou 730030,China) |
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| Abstract: | Hepatocellular carcinoma(HCC) is associated with many specific etiologies.Some epidemiological investigations has shown that dietary iron overload is associated with HCC in Africans.And subsequent studies found that many iron-loading diseases,such as hereditary hemochromatosis,chronic hepatitis C,nonalcoholic fatty liver disease etc,appeared to increase the risk of HCC with the development of these diseases.The carcinogenic potential of these iron-loading diseases is probably mainly associated with genetic ... |
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| Keywords: | liver neoplasms iron |
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