| 替比夫定治疗HBeAgeAg阳性慢性乙型肝炎疗效的预测指标 |
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| 引用本文： | 占国清,谭华炳,张薇薇,李儒贵,谢杏榕,胡波.替比夫定治疗HBeAgeAg阳性慢性乙型肝炎疗效的预测指标[J].临床肝胆病杂志,2011,27(6):608-610. |
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| 作者姓名： | 占国清 谭华炳 张薇薇 李儒贵 谢杏榕 胡波 |
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| 作者单位： | 湖北医药学院附属人民医院感染科,湖北十堰,442000 |
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| 摘 要： | 目的探讨替比夫定治疗HBeAg阳性慢性乙型肝炎（CHB）48周的疗效及其预测指标。方法采用替比夫定（LdT）600 mg/d治疗78例HBeAg阳性CHB患者48周,从性别、年龄、ALT和HBV DNA基线、早期病毒学应答（治疗12周时HBV DNA转阴）为预测因素,分析其对治疗48周疗效的影响。结果性别、年龄与治疗8～48周时HBV DNA转阴无相关性（P〉0.05）;5 ULN≤ALT≤10 ULN组治疗24、36及48周时HBV DNA转阴率高于2 ULN≤ALT≤5 ULN组（P〈0.05,P〈0.01）;HBV DNA 106～105拷贝/ml组治疗48周时ALT复常率和HBV DNA转阴率高于HBV DNA〉107拷贝/ml组（P〈0.05）;早期病毒学应答组治疗48周时HBeAg阴转率ALT复常率和HBV DNA转阴率也高于非应答组（治疗12周时HBV DNA≥500拷贝/ml）（P〈0.05）。结论 ALT、HBV DNA基线、早期病毒学应答可能可以作为预测替比夫定抗HBV疗效的指标
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| 关 键 词： | 肝炎， 乙型， 慢性 肝炎e抗原， 乙型 替比夫定 |
The factors predicting the efficacy of telbivudine in the treatment of HBeAg-positive chronic hepatitis B |
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| ZHAN Guo-qing,TAN Hua-bing,ZHANG Wei-wei,et al..The factors predicting the efficacy of telbivudine in the treatment of HBeAg-positive chronic hepatitis B[J].Chinese Journal of Clinical Hepatology,2011,27(6):608-610. |
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| Authors: | ZHAN Guo-qing TAN Hua-bing ZHANG Wei-wei |
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| Institution: | ZHAN Guo-qing,TAN Hua-bing,ZHANG Wei-wei,et al.(Department of Infectious Diseases,People Hospitol,Hubei Medicine College,Shiyan,Hubei 442000,China) |
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| Abstract: | Objective To study the efficacy of telbivudine in 48-week treatment of HBeAg-positive chronic hepatitis B(CHB) and to find the factors that predict the efficacy of the treatment.Methods 78 patients with HBeAg-positive CHB were treated with Telbivudine,100mg daily for 48 weeks.Their gender,age,ALT and HBV DNA baseline and early virologic response(after 12 weeks of treatment,HBV DNA negative) were selected for predictive factors and their impact on the efficacy of the treatment was analyzed.Results Gender,age... |
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| Keywords: | hepatitis B chronic hepatitis B e antigen telbivudine |
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