Immunohistochemical analysis of a dentinogenic ghost cell tumour |
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| Authors: | A Piattelli M Fioroni L Di Alberti C Rubini |
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| Affiliation: | aDental School, University of Chieti, Chieti, Italy;bDepartment of Oral Medicine, Eastman Dental Institute for Oral Health Care Sciences, London, UK;cDental School, University of Ancona, Ancona, Italy;dDepartment of Pathology, University of Ancona, Ancona, Italy |
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| Abstract: | A dentinogenic ghost cell tumour in an 80-year-old male patient is presented. It is an extremely rare tumour and only 10 cases have been reported in the English literature. The lesion showed odontogenic epithelium, ghost cells, dentinoid, giant cells. The immunohistochemical analysis for Mib-1 and bcl-2 showed a strong positivity of the cells of the odontogenic epithelium, while with p53 only a rare positivity was observed. Completely negative were the ghost cells, giant cells and dentinoid material. In this tumour the cells expressing Mib-1 and bcl-2 could be the cells that proliferate, and that could undergo malignant transformation. |
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| Keywords: | mouth cancer |
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