雌激素受体与绝经后骨质疏松症

检索Pubmed数据库和中国期刊全文数据库文献，总结雌激素受体与绝经后骨质疏松症的关系。雌激素受体以雌激素受体α和雌激素受体β两种亚型广泛存在于人体内。雌激素根据其结合的受体亚型，选择性激活细胞内信号传导途径，表现出多种生物学活性。雌激素对骨吸收的调控作用是通过某些细胞因子的介导和直接对破骨细胞作用完成的。近年来对选择性雌激素受体调节剂对两种不同受体亚型的特异性作用的研究已成为热点。

Relationship between estrogen receptor and postmenopausal osteoporosis

Both Pubmed database and China Academic Journals Full-text Database were retrieved to search the articles about the relationship between estrogen receptor (ER) and postmenopausal osteoporosis. There are two subtypes of ER widely distributed in the human body, ER α and ER β. According to the bound receptor subtypes, estrogen activates selectively intracellular signaling pathway, and expresses various biological activities. The regulation of estrogen on bone resorption is effected through being mediated by certain cytokines or directly functioning on osteoclasts. In recent years, the specific effect of selective ER modulator on two different receptor subtypes has become the hot topic for treatment of osteoporosis.