氟西汀并用阿米替林治疗难治性抑郁症临床研究

目的：观察氟西汀合并阿米替林对难治性抑郁症的疗效和不良反应。方法：对42例难治性抑郁症患者随机分为合用组（氟西汀合并阿米替林22例）和单用组（氟西汀20例）治疗6周,采用汉密尔顿抑郁量表（HAMD）、临床疗效总评量表（CG I）评定疗效,以副反应量表（TESS）评定不良反应。结果：第1、2、4、6周末两组间HAMD及CG I评分比较,合用组低于单用组,差异有显著性;治疗6周末70.8%显著高于单用组的41%;两组TESS评分间期比较差异无显著性。结论：氟西汀合并阿米替林对难治性抑郁症的疗效优于单用氟西汀且起效快。

A clinictrol control study of combined fluoxetine and amitriptylin in the treatment of refractory depression

Objective: To observe the clinical efficacy and side effects of fluoxetine combined with amitriptylin for treating refractory depression.Methods:Forty-two Patients with refractory depression were randomly assigned to study group(fluoxetine combined with amitriptylin,n=22) and control group(single fluoxetine,n=20) for 6 weeks,Effects and side reactions were evaluated with Hamilton depression scale(HAMA),Clinical global impression(CGI) and the treatment emergert symptoms scale(TESS) before and after the treatment.Results: HAMD and CGI scores of the study group were significantly lower than those of the control group at the end of the 1.2.4and 6 weeks treatment.The significant improvement rate was remarkably higher in the study group(70.8%) than in the control group(40%).Nosignificant difference of TESS scores was found between two groups.Conclusions: fluxetine combined with amitriptylin to treat refractory depression has better officacy and fewer adverse events.