Evaluation of inflammatory status of atherosclerotic carotid plaque before thromboendarterectomy using delayed contrast-enhanced subtracted images after magnetic resonance angiography |
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Authors: | Papini Giacomo D E Di Leo Giovanni Tritella Stefania Nano Giovanni Cotticelli Biagio Clemente Claudio Tealdi Domenico G Sardanelli Francesco |
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Affiliation: | aScuola di Specializzazione in Radiodiagnostica, Facoltà di Medicina e Chirurgia, Università degli Studi di Milano, via Festa del Perdono 7, Milan, Italy;bUnità di Radiologia, IRCCS Policlinico San Donato, Piazza E. Malan 20097 San Donato Milanese, Milan, Italy;cDipartimento di Scienze Medico-Chirurgiche, Università degli Studi di Milano, Piazza E. Malan 20097 San Donato Milanese, Italy;dUnità di Chirurgia Vascolare, IRCCS Policlinico San Donato, Piazza E. Malan 20097 San Donato Milanese, Italy;eUnità di Anatomia Patologica, Istituto Clinico Sant’Ambrogio, Via Faravelli 16 - 20149 Milan, Italy |
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Abstract: | ObjectiveTo investigate the correlation among carotid plaque contrast enhancement (CPCE) at MRI, inflammatory cell infiltration (ICI) at histopathology, and carotid stenosis degree.Materials and methodsTwenty-eight patients (19 males; mean age 67 ± 9 years) scheduled for thromboendarterectomy prospectively underwent 1.5-T MR imaging using: (a) axial T1-weighted gradient-echo (T1wGRE) sequence centered on carotid bifurcations; (b) contrast-enhanced MR angiography (CE-MRA) with 0.1 mmol/kg of gadobenate dimeglumine; (c) enhanced axial T1wGRE sequence as in (a), 3 min after contrast injection. A three-point score system (absent, focal, wide) was used to assess CPCE on native and subtracted MRI images (c minus a) and ICI at histopathology. Carotid stenosis degree was determined on CE-MRA.ResultsSix CPCE studies were discarded due to patient movement. In the remaining 22 studies, CPCE was absent, focal and wide in 13, 6 and 3 cases, respectively; ICI was absent, focal and wide in 13, 7 and 2 cases, respectively (k = 0.57). On CE-MRA 21/28 stenoses were severe and 7/28 moderate. There was no correlation either with ICI (p = 1.000, n = 28) or CPCE (p = 0.747, n = 22).ConclusionThe correlation between CPCE and ICI suggests a role for CPCE as an independent marker of plaque inflammation. |
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Keywords: | Magnetic resonance imaging Magnetic resonance angiography Contrast material Atherosclerosis Carotid stenosis |
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