Analysis for the potential of polystyrene and TiO2 nanoparticles to induce skin irritation, phototoxicity, and sensitization |
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| Authors: | Yoon-Hee Park Sang Hoon Jeong Sang Min Yi Byeong Hyeok Choi Yu-Ri Kim In-Kyoung Kim Meyoung-Kon Kim Sang Wook Son |
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| Affiliation: | aLaboratory of Cell Signaling and Nanomedicine, Department of Dermatology and Division of Brain Korea 21 Project for Biomedical Science, Korea University College of Medicine, Seoul, South Korea;bDepartment of Biochemistry and Molecular Biology, Korea University College of Medicine, Seoul, South Korea |
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| Abstract: | The human skin equivalent model (HSEM) is well known as an attractive alternative model for evaluation of dermal toxicity. However, only limited data are available on the usefulness of a HSEM for nanotoxicity testing. This study was designed to investigate cutaneous toxicity of polystyrene and TiO2 nanoparticles using cultured keratinocytes, a HSEM, and an animal model. In addition, we also evaluated the skin sensitization potential of nanoparticles using a local lymph node assay with incorporation of BrdU. Findings from the present study indicate that polystyrene and TiO2 nanoparticles do not induce phototoxicity, acute cutaneous irritation, or skin sensitization. Results from evaluation of the HSEMs correspond well with those from animal models. Our findings suggest that the HSEM might be a useful alternative model for evaluation of dermal nanotoxicity. |
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| Keywords: | Polystyrene TiO2 Phototoxicity Skin irritation Skin sensitization |
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