Effect of obesity on alveolar bone loss in experimental periodontitis in Wistar rats |
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Authors: | Verzeletti Giliano Nicolini Gaio Eduardo José Linhares Daniele Sigal Rösing Cassiano Kuchenbecker |
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Institution: | Lutheran University of Brazil, Canoas, RS, Brazil. gilianonv@hotmail.com |
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Abstract: | Obesity has been linked to higher inflammatory status and periodontal breakdown.Objective The purpose of this study was to investigate the effect of obesity on alveolar
bone loss in experimental periodontitis in rats. Material and Methods Twenty-four female Wistar rats were randomly divided into two groups: obese
(n=13), which were fed with "cafeteria diet" (CAF diet - high amounts of sucrose
and fat) for 90 days in order to gain weight, and non-obese (n=11) regularly fed
rats. Ligature-induced experimental periodontitis was created in all animals. Body
weight differed statistically between obese and non-obese groups (277.59 and
223.35 g, respectively) at the moment of the ligature placement. Morphometric
registration of alveolar bone loss was carried out after 30 days of ligature
placement to determine the effect of obesity on the progression of experimental
periodontitis. Results Intra-group comparisons showed significantly higher alveolar bone loss mean
values in maxillary teeth with ligature (P<0.05). Alveolar
bone loss mean (SD), mm] was not statistically different between obese and
non-obese groups 0.71 (0.09) and 0.65 (0.07) mm, respectively]. However, when
palatal sides are analyzed separately, obese group presented significantly higher
alveolar bone loss (P<0.05) as compared to non-obese 0.68
(0.12) and 0.53 (0.13) mm, respectively]. Conclusions In spite of the weak differences, it is possible to conclude that the progression
of alveolar bone loss in ligature-induced periodontitis can be potentially
influenced by body weight in rats. |
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Keywords: | Body weight Inflammation Periodontal diseases |
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