Perforin-dependent CD4+ T-cell cytotoxicity contributes to control a murine poxvirus infection |
| |
Authors: | Fang Min Siciliano Nicholas A Hersperger Adam R Roscoe Felicia Hu Angela Ma Xueying Shamsedeen Ahamed R Eisenlohr Laurence C Sigal Luis J |
| |
Affiliation: | Immune Cell Development and Host Defense Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA. |
| |
Abstract: | CD4(+) T cells are generally regarded as helpers and regulators of the immune response. Although cytolytic CD4(+) T cells have been described, whether those generated during the course of a viral infection play a role in virus control remains unknown. Here we show that during acute infection with ectromelia virus, the mouse homolog of the human virus of smallpox, large numbers of CD4(+) T cells in the draining lymph node and liver of resistant mice have a cytotoxic phenotype. We also show that these cells kill targets in vivo in a perforin-dependent manner and that mice with specific deficiency of perforin in CD4(+) T cells have impaired virus control. Thus, perforin-dependent CD4(+) T-cell killing of infected cells is an important mechanism of antiviral defense. |
| |
Keywords: | CD4+ T lymphocytes cytotoxic T lymphocytes viral immunology viral pathogenesis |
本文献已被 PubMed 等数据库收录! |
|