| 大孔吸附树脂分离岩黄连总生物碱的研究 |
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| 引用本文： | 李倩霞,蒋林,杨得坡,陈建萍,王冬梅.大孔吸附树脂分离岩黄连总生物碱的研究[J].中国医药工业杂志,2009,40(10). |
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| 作者姓名： | 李倩霞 蒋林 杨得坡 陈建萍 王冬梅 |
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| 作者单位： | 李倩霞,蒋林,杨得坡,王冬梅(中山大学药学院生药学与天然约物化学实验室,广东广州,510006);陈建萍(香港大学中医药学院,香港) |
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| 基金项目： | 广西科学技术研究与开发计划项目，广东省教育部产学研结合项目，广东省科技厅国际合作项目 |
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| 摘 要： | 利用大孔吸附树脂分离岩黄连中的总生物碱,采用静态和动态吸附-解吸附方法,以总生物碱和脱氢卡维丁含量为指标,考察了6种大孔吸附树脂对岩黄连总生物碱的吸附能力,其中D101型大孔吸附树脂的比吸附量和比洗脱量均较高.优化后的提取上艺为:上样药液原药材浓度0.2g/ml,吸附流速为2BV/h,解吸附溶剂为60%乙醇(3BV),所得岩黄连提取物中总牛物碱含量人于60%.
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| 关 键 词： | 岩黄连 大孔吸附树脂 生物碱 脱氢卡维汀 纯化 |
Extraction of Total Alkaloids from Corydalis saxicola Bunting by the Macroporous Resin |
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| Abstract: | The total alkaloids were extracted from Corydalis saxicola Bunting by macroporous resin.Six different macroporous resins were used for extraction of the total alkaloids and dehydrocavidine by using static and dynamic adsorption-desorption experiments.The specific adsorption capacity and eluting of D101 macroporous resin were comparatively high.The optimum parameters of the purification process were established as the sample concentration of 0.2 g/ml at the absorption ? ow rate of 2 BV/h and with 3 BV of 60% ethanol as the desorption solvent.The contents of total alkaloids in the purifi ed extract were over 60%. |
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| Keywords: | Corydalis saxicola Bunting macroporous resin alkaloids dehydrocavidine purification |
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