膀胱移行细胞癌E—Cadherin和α—Catenin的表达及临床意义

目的：探讨上皮钙粘素（E－Cadherin)和α－连环素（α-Cadherin)在膀胱移行细胞癌中的表达及其生物学行为之间的关系。方法：采用免疫组织化学SABC法检测E－Cadherin和α-Catenin在65例膀胱移行细胞癌石蜡标本中的表达。结果：E－Cadherin在G1、G2、G3级和Tis-T1,T2-T4期肿瘤中的正常表达率分别为76．2％、34．8％、4．8％和54．1％、17．9％，α-Catenin在G1、G2、G3级和Tis-T1,T2-T4期肿瘤中的正常表达率分别为71．4％、34．8％、4．8％和51．4％、17．9％，二者的表达情况均与肿瘤的病理分级和临床分期密切相关（P＜0．01）；65例肿瘤标本中E-Cadherin 和α-Catenin表达同时正常或异常者占83．1％，二者表达之间具有显著相关性（P＜0．01）；E－Cadherin或α-Catenin正常和异常表达者间癌复发差异具有显著性意义（P＜0．05）。结论：E－Cadherin和α-Catenin的表达情况可以作为监测膀胱移行细胞癌恶性程度及复发的重要指标。

Expression of E-Cadherinand

To detect the expression of E-Cadherin and α-Catenin in bladder transitional cell carcino ma (BTCC) and analyze its correlation with the biological behavior of BTCC. Methods:The immunohistochemical staining with strept avidin-biotin-peroxidase complex method (SABC method) was used to detect the expression? of E-Cadherin and α-Catenin in 65 paraffin embeded BTCC tissues. Results :The normal expression rate of E-Cad herin was 76.2％ of G1 ,34.8％ of G2,4.8％ of G3,54.1％ of Tis～T1 and 17.9％ of T2～T4 tumors respectively. The normal expression rate of α-Catenin was 71.4％ of G1,34.8％ of G2,4.8％ of G3, 51.4％ of Tis～T1 and 17.9％ of T2～T4 tumors respectively. The expression of either E-Cadherin or α-Catenin was significantly corre lated with pathological grade,clinical stage of BTCC ( P＜0.01). E-Cadherin and α-Catenin expression was con comitantly either normal or abnormal in 83.1％ of tumors. The correlation between E-Cadherin and α-Catenin ex pression was significant ( P＜0.01). There was a significant difference in recurrence rate between normal E-Cad herin expression team and abnormal E-Cadherin expression team and between normal α-Catenin expression team and abnormal α-Catenin expression team ( P＜0.05). Conclusions: Detection of E-Cadherin and α-Catenin ex pression have a practical significance in assessing the malignancy and recurrence of BTCC.