The evidence for the involvement of the 5-HT1A receptor in 5-HT syndrome induced in mice by tryptamine |
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| Authors: | J Yamada Y Sugimoto K Horisaka |
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| Affiliation: | Department of Pharmacology, Kobe Women's College of Pharmacy, Japan. |
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| Abstract: | The involvement of the 5-HT1A receptor in the 5-HT syndrome (head weaving and hindlimb abduction) induced in DBA mice by tryptamine was investigated. Methysergide, (-)propranolol and spiperone suppressed both the head weaving and hindlimb abduction induced by tryptamine. However, ketanserin and ICS 205-930 did not affect them. Haloperidol induced small decreases in the head weaving, but had no effect on the hindlimb abduction. These results indicate that the 5-HT syndrome induced by tryptamine in mice is mediated by the 5-HT1A receptor. Therefore, 5-HT syndrome may also be associated with the 5-HT1A receptor in mice, as it is in rats. |
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