番茄红素对2型糖尿病患者炎症因子与颈动脉内膜中层厚度的影响

目的探讨2型糖尿病(T2DM)患者血清炎症因子水平与颈动脉内膜中层厚度(CIMT)的关系及番茄红素(Lyc)的干预效果。方法选取T2DM患者130例随机分为:A组(干预组)64例,给予Lyc胶囊30mg/d;B组(对照组)66例,不服用Lyc但给予安慰剂。两组患者均采集入组时和干预后6个月的空腹血清,监测血糖、生化指标、炎症因子和CIMT。结果 Lyc干预6个月后,A组IL-6、TNF-α、hs-CRP、NF-κB水平显著降低,均低于B组(P<0.05),B组上述炎症因子水平变化差异无统计学意义(P>0.05);干预后A组患者CIMT及颈动脉斑块发生率较干预前及B组明显下降;T2DM患者CIMT与炎症因子水平相关,多元回归分析表明NF-κB、HbAlc和hs-CRP是CIMT的独立影响因素(决定系数R2=0.612,P=0.000)。结论 T2DM患者炎症因子水平是CIMT的独立预测因素,Lyc可能通过降低炎症因子水平而抑制T2DM患者早期动脉粥样硬化的发生、发展。

EFFECTS OF LYCOPENE ON CYTOKINES AND CAROTID INTIMA-MEDIA THICKNESS IN TYPE 2 DIABETIC PATIENTS

Objective To examine whether inflammatory cytokines were related to carotid artery intima media thickness(CIMT) in type 2 diabetic patients and evaluate the effect of lycopene(Lyc) on them.Methods One hundred and thirty T2DM patients without major vascular complications were recruited and randomly divided into two groups: Lyc treated group(A group,n=64) and control group(B group,n=66).In A group,the patients were given orally Lyc 30 mg twice daily for 6 months.In B group,the patients were given the placebo for 6 mo.Their biochemical indicators and inflammatory cytokines and carotid intima-media thickness were measured before and after the treatment.Results After treatment with Lyc,the interleukin-6(IL-6),tumor necrosis factor(TNF-α),(hypersensitive 3 C-reactive,hs-CRP),and nuclear factor kappa B(NF-KB) decreased significantly(P<0.05).Most data had no marked changes in the B group(P>0.05).After treatment with Lyc,CIMT and the incidence of carotid atherosclerotic(AS) plaque decreased significantly(P<0.05).Pearson correlation analysis showed that CIMT was positively correlated with IL-6,TNF-α,hs-CRP and NF-κB(P<0.05).Multivariate regression analysis showed that NF-κB,HbAlc and hs-CRP concentration were independent predictors of CIMT in this cohort(R2 =0.612,P=0.000).Conclusion High concentration of inflammatory cytokines is risk factor for preclinical AS in T2DM patients.Lyc may delay the occurrence and development of AS via decreased inflammatory cytokines concentration.