Malignant Tumor Following Renal Transplantation（肾移植术后恶性肿瘤）

目的 总结我们中心肾移植病人恶性肿瘤的发病情况，探讨预防及治疗措施。方法 回顾分析我们中心从1979年12月～2001年5月1037例临床资料。结果 在1037例肾移植病人中发现15例恶性肿瘤，发病率为1．4％。其中最多的是肝癌(6／15)，其次是卡帕氏肉瘤(4／15)，再其次是肺癌(2／15)。结论 肾移植术后病人恶性肿瘤的发病率较一般人群高；治疗的效果取决于早期发现肿瘤并及早施行手术；同时，用最小的免疫抑制剂维持移植肾的正常功能。Objective To summarize the prevalence of malignant tumor after renal transplantation and investigate the measures of prevention and treatment.Methods The clinical data of 1037 cases undergoing renal transplantation in our center between Dec. 1979 and May 2001 were retrospectively analyzed.Results Of the 1037 patients undergoing renal transplantation, 15 cases were diagnosed as having malignant tumor with the incidence being 1.4%. The most common types of tumors were liver cancer (6/15), followed by Kaposi‘ s sarcoma (4/15) and pul-monary cancer (2/15).Conclusion There is a higher incidence of malignant tumor in the renal transplantation recipients than general populations. The curative effects of treatment depended on early diagnosis and early surgical operation. At the same time, the least dosage of immunosuppressant was used to maintain normal function of the graft.