| 绿茶抑制黄曲霉毒素B_1致大鼠肝癌作用的时间一效应关系 |
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| 引用本文： | 李瑷,严瑞琪,覃国忠,覃柳亮,段小娴.绿茶抑制黄曲霉毒素B_1致大鼠肝癌作用的时间一效应关系[J].广西医科大学学报,1989(1). |
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| 作者姓名： | 李瑷 严瑞琪 覃国忠 覃柳亮 段小娴 |
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| 作者单位： | 广西肿瘤研究所病理研究室，广西肿瘤研究所病理研究室，广西肿瘤研究所病理研究室，广西肿瘤研究所病理研究室，广西肿瘤研究所病理研究室 |
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| 摘 要： | 本研究应用我室建立的AFB_1致大鼠肝癌作用短期体内实验模型,探讨绿茶在动物摄入AFB_1前、中、后等不同时期,对AFB_1致肝癌作用的影响.结果表明,绿茶与某些已知的抑癌物不同:它对AFB_1致肝癌作用的抑制效果不受使用时间的影响,不论用于给AFB_1前、中、后期,均有明显的抑制作用.本结果为绿茶作为一种安全有效的抑制AFB_1致肝癌作用的化学预防剂,再次提供有力的依据.
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| 关 键 词： | 绿茶 AFB_1 肝癌 化学预防 γ-GT阳性肝细胞灶 |
TIME-RELATED INHIBITORY EFFECT OF GREEN TEA DIET ON AFLATOXIN B_1-INDUCED HEPATOCARCINOGENESIS IN RAT |
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| Institution: | Department of Pathology,Guangxi Cancer Institute Li Yuan,et al |
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| Abstract: | Green tea diet was given to the rats either before, during or after AFB_1 exposure in order to test the time-effect of green tea on AFB_1-induced hepatocarcinogenesis for short-term model in vivo experiments.The results showed; that no matter at what time it was given, green tea always exerted significant inhibitory effect on the development of AFB_1-induced hepatocarcinogenesis.This was rather different from the time-related effect of some other chemicals such as phenobarbital, BHT and BHA.This result suggests that green tea can be used as a safe and effective chemoprevention agent for inhibiting AFB_1-induced hepatocarcinogenesis. |
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