11省市代谢综合征患者中心脑血管病发病率队列研究

目的　探讨队列人群代谢综合征与心脑血管病发病率的关系。方法　采用 1 1省市队列人群 (35～ 64岁 )共 2 7739人于 1 992年进行基线危险因素调查的资料 ,计算队列人群代谢综合征患者在观察终点心脑血管病事件的人年标化发病率 ,用Cox回归模型预测危险因素水平与发病率之间的相关性。结果　 (1 ) 1 1省市队列人群代谢综合征患者心脑血管病人年标化发病率明显高于无代谢综合征者 (分别为 652 .3 1 0万和 2 0 6 .7 1 0万 ,二者RR =3 .1 2 ,P <0 .0 0 1 ) ;(2 )有高血压、低高密度脂蛋白和高腰围者心脑血管病人年标化发病率最高 (男性 91 0 .2 1 0万 ,女性 930 .7 1 0万 ) ;(3)男性年龄、吸烟、体重指数、总胆固醇和代谢综合征是心脑血管病发病的最重要的预测因素 ,女性为年龄、体重指数和代谢综合征。结论　 1 1省市队列人群代谢综合征患者心脑血管病人年标化发病率明显高于无代谢综合征者 ,代谢综合征是心脑血管病发病的最重要的预测因素 (尤其脑血管病 ) ,心脑血管病危险因素的一级和二级预防势在必行

A study on the incidence of cardiovascular disease on the metabolic syndrome in 11 provinces in China

Objective To explore the association of metabolic syndrome with CVD in a cohort study involing 11 provinces. Methods A cohort study was carried out in a population of 27 739 subjects (age 35 64 years). A baseline survey on the risk factor of cardiovascular disease was done in 1992. Incidence rate and relative risk were calculated for metabolic syndromes. Results (1) The age standardized incidence rate of cardiovascular disease for metabolic syndromes (MS) was higher than those without (MS) in this cohort (MS 652.3/ 100 000 , not MS 206.7/ 100 000 , RR = 3.12 , P < 0.001 ). (2)The incidence rate of cardiovascular disease for patients with hypertension but low HDL cholesterol and high waist was the highest ( 910.2/ 100 000 in man, 930.7/ 100 000 in woman) among all metabolic syndromes patients. (3) The predictive risk factors for cardiovascular disease were age, cigarette smoking, BMI,total cholesterol and metabolic syndrome in men, with age, BMI and metabolic syndrome in women. Conclusion The incidence rate of cardiovascular disease on the metabolic syndrome was high in 11 provinces in China. Age, BMI and metabolic syndrome were the predictive risk factors of cardiovascular disease (especially of cerebrovascular disease). It is essential to prevent risk factors of cardiovascular disease in primary and secondary prevention programs in general population.