| 盐酸特拉唑嗪的合成工艺改进 |
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| 引用本文： | 王立甫,徐化平.盐酸特拉唑嗪的合成工艺改进[J].齐鲁药事,2007,26(3):177. |
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| 作者姓名： | 王立甫 徐化平 |
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| 作者单位： | 滕州市中医院,山东,滕州,277500 |
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| 摘 要： | 目的改进盐酸特拉唑嗪的合成工艺。方法以无水哌嗪为起始原料,经酰化、还原、胺化、成盐等反应制得盐酸特拉唑嗪。结果与结论降低了成本,提高了收率,适合工业化生产。
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| 关 键 词： | 特拉唑嗪 合成 工艺改进 |
| 文章编号： | 1672-7738(2007)01-0177-01 |
Synthesis technology improvement of terazosin hydrochloride |
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| WANG Li-fu,XU Hua-ping.Synthesis technology improvement of terazosin hydrochloride[J].qilu pharmaceutical affairs,2007,26(3):177. |
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| Authors: | WANG Li-fu XU Hua-ping |
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| Abstract: | OBJECTIVE To improve the synthetic procedure of terazosin hydrochloride.METHODS Terazosin hydrochloride was synthesized from anhydro-piperazine via acylation,reduction,amination,salification etc.RESULTS and CONCLUSION The new method can reduce the cost,enhance the yield,and it was suitabale for pharmaceutical industry. |
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| Keywords: | Terazosin synthesis technology improvement |
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