杭州市传染性非典型肺炎接触人群感染状况调查

目的分析杭州市2003年传染性非典型肺炎(严重急性呼吸综合征,SARS)人群感染状况及其流行特征.方法对2003年杭州市SARS病例的密切接触者、接触者及人群进行流行病学调查和SARS抗体测定.结果调查117名,其中密切接触者11名,一般接触者33名,普通人群73名;发病前接触27名,发病后接触7名,两者都接触8名,未接触75名.密切接触者以15～34岁为主,占81.82%.11例密切接触者中,与SARS病例在发病前10天接触有7人,发病后接触有2人,两者都接触2人;接触距离在1米以内的4人,其中亲属3人;3人亲属中有2人在发病后接触,接触方式主要为同进餐与同处室.其余接触者大多为邻居和同事,与SARS病人在发病后接触最多的方式是与病人谈话或/和同封闭通道.117名调查者的双份血清SARS抗体测定IgG均阴性.3例SARSA病人发病后第2周开始SARS IgG阳性,发病后3个月仍阳性.结论杭州市人群中未受到SARS病毒的感染,采取综合性防制是控制SARS流行的关键措施.

An Investigation on the Infection of Severe Acute Respiratory Syndrome (SARS) in the Population of Hangzhou City

Objective To analyze the Status of Severe Acute Respiratory Syndrome (SARS) Infection in the Population of Hangzhou City in 2003, to understand its epidemic characteristics and involved factors, and to evaluate the efficacy of preventive measure.Methods An epidemiologic survey and the detection of serum SARS antibody were undertaken in the close contactors and ordinary contactors with patients suffering SARS in Hangzhou City in 2003.Results 117 individuals were surveyed including 11 close contactors, 33 ordinary contactors and 73 normal people, which included 27 individuals contacting with preclinical patients, 7 individuals contacting with clinical patients, 8 individuals contacting with both of the two kinds of patients and 73 normal individuals never contacting with patients. In 11 close contactors, there were 7 individuals contacting with preclinical patients, 2 individuals contacting with clinical patients and 2 individuals contacting with these both two kinds of patients, which included 3 relatives and 1 other contacting with preclinical or clinical patients within one-meter range. In the 3 relative contactors, there were 2 individuals contacting with clinical patients with the manner of having dining together or living in the same room. Other contactors were mainly neighbors or colleagues. The commonest manner contacting with clinical patients were talking with them or in the same close room. The serum SARS antibody for them was detected all negative, but the 3 SARS cases presented positive response from the second week to the third month since appeared clinical symptoms.Conclusions In Hangzhou City, SARS virus did not infected the contactors in this epidemic. The key measure for controlling SARS epidemic is the comprehensive preventive measures based on the acquired experience.