| 禁食对小鼠杏仁核HAP1表达的影响 |
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| 引用本文： | 许瑞娜,汪薇曦,张亦农. 禁食对小鼠杏仁核HAP1表达的影响[J]. 湖北中医药大学学报, 2007, 9(1): 32-34 |
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| 作者姓名： | 许瑞娜 汪薇曦 张亦农 |
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| 作者单位： | 湖北中医学院解剖组胚教研室 湖北武汉430065(许瑞娜)，华中科技大学同济医学院解剖学系组织胚胎学室 湖北武汉430030(汪薇曦，张亦农) |
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| 摘 要： | 目的探讨小鼠杏仁核中的亨廷顿蛋白相关蛋白HAP1(huntingtin associated protein 1,HAP1)的分布及是否与饥饿有关。方法采用半定量免疫印迹法(Western blotting)检测禁食过程小鼠杏仁核HAP1表达的变化。应用免疫组织化学染色法观察禁食对杏仁核HAP1表达的影响。结果连续禁食1日、2日、3日、4日的小鼠杏仁核的HAP1含量与正常进食的小鼠相比,呈逐渐增多的趋势。其HAP1阳性细胞的表达随禁食时间的延长显著增高。结论HAP1与饥饿有关,并有可能参与了食欲的调节。
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| 关 键 词： | 亨廷顿蛋白相关蛋白1 杏仁核 饥饿 禁食 小鼠 |
| 文章编号： | 24054175 |
| 修稿时间： | 2006-11-30 |
The Influence of Food Deprivation on the Expression of HAP1 in the Hypothalamic of Mice |
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| XU Rui-na,WANG Wei-xi,ZHANG Yi-nong. The Influence of Food Deprivation on the Expression of HAP1 in the Hypothalamic of Mice[J]. Journal of Hubei University of Chinese Medicine, 2007, 9(1): 32-34 |
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| Authors: | XU Rui-na WANG Wei-xi ZHANG Yi-nong |
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| Affiliation: | 1. Hubei College of TCM ,Wuhan 430065; 2. Division of Histology and Embryology,Department of Anatomy, Tongji Medical College, Wuhan 430030 |
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| Abstract: | Objective: To probe for if huntingtin associated protein 1(HAP1) is involved in hungry.Methods: Western blotting was used to observe the effect of food-deprivation on expressing of HAP1 in the amygdala of the mouse.Method of immunohistochemistry was used to determine the change of HAP1 in the amygdala.Results: It was detected by western blotting that the HAP1 expression in the amygdala increases when food-deprivation continued.By immunohistochemistry,HAP1 immunoreactivity was shown to enhanced in the amygdala.Conclusion: HAP1 might be involved in hungry and participate in appetite regulation. |
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| Keywords: | Huntingtin associated protein 1 Amygdala Mice Food deprivation |
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